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货期:14天
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MedChemExpress LLC
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NMPA-Approved Drug Library
MCE 国际站:NMPA-Approved Drug Library
From target identification to clinical research, traditional drug discovery and development is a time-consuming and costly process, which also bears high risk. Compared with traditional drug discovery, drug repositioning or repurposing, also known as old drugs for new uses can greatly shorten the development cycle and reduce development cost, which has become a new trend of drug development. After undergoing clinical trials, approved drugs have identified bioactivities, good pharmacokinetic characteristics and safety, which can greatly improve the success rate of drug discovery. A number of successes have been achieved, such as metformin for type 2 diabetes and thalidomide for leprosy and multiple myeloma, etc.MCE provides a unique collection of 1357 China NMPA (National Medical Products Administration) approved compounds, which have undergone extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. MCE NMPA-Approved Drug Library is a good tool for drug repurposing which could dramatically accelerate drug development.
Description & Advantages:
• A unique collection of 1357 approved compounds for high throughput screening (HTS) and high content screening (HCS).
• Used in the research of oncology, cardiology, anti-inflammatory, immunology, dermatology, endocrinology, neurology, and more.
• A useful tool for researching new targets of marketed old drugs.
• All compounds have been approved by the NMPA.
• Structurally diverse, bioactive, and cell permeable.
• More detailed compound information with structure, IC50, and brief introduction.
• NMR and HPLC validated ensure high purity.
• All compounds are in stock and continuously updated.
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文献和实验In Silico Drug Exploration and Discovery Using DrugBank
and drug target database that contains information on nearly 5000 drugs, including >1200 FDA?approved small molecule and biotech drugs as well as >3200 experimental drugs. Additionally, more than 14,000 protein or drug target sequences are linked
In Vitro Cytotoxicity Assessment
The most frequent reason cited for withdrawal of an approved drug is toxicity, yet no simple solution exists to adequately predict such adverse effects. Compound prioritization and optimization during in vitro screening cascades
Selecting, Acquiring, and Using Small Molecule Libraries for High‐Throughput Screening
. 4:177?191 © 2012 by John Wiley & Sons, Inc. Keywords: small molecule library; high?throughput screening; chemical biology; drug discovery
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