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- MedChemExpress(MCE)
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- HY-133122
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1515888-53-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1870.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥700.0 |
| 规格： | 5 mg | 产品价格： | ￥1700.0 |
| 规格： | 10 mg | 产品价格： | ￥2750.0 |
| 规格： | 25 mg | 产品价格： | ￥4765.0 |
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UCB-9260
CAS No. : 1515888-53-5
MCE 国际站：UCB-9260
产品活性：UCB-9260 是一种口服活性小分子，通过稳定三聚体的不对称形式抑制肿瘤坏死因子 (TNF) 信号传导。UCB-9260 对肿瘤坏死因子的选择性高于其他超家族成员，并与肿瘤坏死因子结合，其 Kd 值为 13 nM。
研究领域：Apoptosis
作用靶点：TNF Receptor
In Vitro: UCB-9260 (0-10 μM)?inhibits NF-κB with a geometric mean IC50?of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells.
?UCB-9260?inhibits TNF-dependent cytotoxicity with a geometric mean IC50?of 116 nM and a geometric mean IC50?of 120 nM, using human and mouse TNF, respectively.
In Vivo: UCB-9260 (150?mg/kg; p.o.;twice daily?for 7 days) shows a significant reduction of the clinical score.
?UCB-9260?(10-300?mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment in adult male Balb/c mice.
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