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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
397864-44-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg/200 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥406.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥170.0 |
| 规格： | 5 mg | 产品价格： | ￥343.0 |
| 规格： | 10 mg | 产品价格： | ￥550.0 |
| 规格： | 25 mg | 产品价格： | ￥991.0 |
| 规格： | 50 mg | 产品价格： | ￥1540.0 |
| 规格： | 100 mg | 产品价格： | ￥2310.0 |
| 规格： | 200 mg | 产品价格： | ￥3000.0 |
| 规格： | 500 mg | 产品价格： | ￥5000.0 |
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Fluticasone furoate
CAS No. : 397864-44-7
MCE 国际站：Fluticasone furoate
产品活性：Fluticasone furoate 是一种局部，鼻内，增强亲和力的合成的三氟皮质类固醇，Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎和抗哮喘活性，并且全身暴露率低。Fluticasone furoate 可用于过敏性鼻炎的研究。
研究领域：GPCR/G Protein
作用靶点：Glucocorticoid Receptor
In Vitro: Fluticasone furoate comes in a nasal spray, as an aqueous suspension of micronized fluticasone furoate for topical administration to the nasal mucosa by means of a metering, atomizing spray pump.
Fluticasone furonate displays great potency in inhibiting tumor necrosis factor synthesis and action. Fluticasone furonate is also potent in preventing damage to cultured human lung epithelial cells by different stimulus.
In Vivo: Fluticasone furonate is 99.4% bound to plasma protein in vitro and other research indicated extensive first-pass metabolism of the absorbed drug. Protein binding is highly relevant because only the unbound free drug can exert an effect at the receptor site. Clearance of Fluticasone furonate is primarily by hydrolysis in the liver by the cytochrome P450 isozyme (CYP) 3A4 that converts the drug to the 17β-carboxylic acid metabolite (M10), which displays low glucocorticoid receptor agonist potency. Fluticasone furonate is excreted mainly in the feces, with only minor amounts in the urine.
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文献和实验pharmacology, indications and usage, contraindications, warnings, precautions, adverse reactions, dosage and administration, patient information, how it is supplied, and therapeu http://www.rxlist.com/cgi/generic/fexofen.htm 资源类型：专业网址 20. Fluticasone
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