- ￥909 - 3500
- MedChemExpress(MCE)
- 美国
- HY-122347A
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
相关阅读
源叶生物 十万种现货试剂速发，品质稳、品类全，实验不再等！Takara 秋促来袭，提取+反转录+定量套装仅 1200 元abinScience 体内级抗体 全年锁价 低至 ￥1200阿拉丁 22万+ 科研级产品现货速发，品质严控、科研无忧- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
GW823296 maleate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
579475-24-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3277.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥909.0 |
| 规格： | 5 mg | 产品价格： | ￥2000.0 |
| 规格： | 10 mg | 产品价格： | ￥3500.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Orvepitant maleate
CAS No. : 579475-24-4
MCE 国际站：Orvepitant maleate
产品活性：Orvepitant maleate (GW823296 maleate) 是一种有效，选择性，口服活性且耐受性良好的 neurokinin-1 (NK-1) 受体拮抗剂，对人 neurokinin-1 受体的 pKi 为 10.2。Orvepitant maleate 可以穿越血脑屏障。Orvepitant maleate 可用于抑郁症和慢性顽固性咳嗽的研究。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Neurokinin Receptor
In Vitro: Orvepitant (Compound 3a) is further characterized in terms of the ability to functionally inhibit substance P (SP)-induced release of cytosolic Ca2+ in human neurokinin-1 receptor (hNK1)-CHO cells. Orvepitant (0.3-10 nM), pre-incubated for 1 h at 37℃ before adding the agonist SP, produces a non-surmountable antagonism of agonist concentration-response curve. For Orvepitant apparents pKB value of 10.30.
In Vivo: Orvepitant (Compound 3a; 0.3-10 mg/kg; Oral administration; marmoset) treatment shows a dose dependant reduction of the number of postures was observed at 1 mg/kg (34.9% reduction), 3 mg/kg (36.6% reduction) and 10 mg/kg (46.4% reduction), suggesting a potential anxiolytic-like effect of the compound.
Orvepitant (compound 3a) shows an oral bioavailability (F) of 17% in rat and 55% in dog, plasma clearance (Clp) of 29 mL/min/kg in rat and 6 mL/min/kg in dog and a half-life of 2.3 h in rat and 6.1 h in dog. As far as the brain penetration in rats is concerned, a B/P ratio of 1.2 is observed 5 min after the i.v. administration of a 1 mg/kg dose of Orvepitant.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Clinical Compound Library | CNS-Penetrant Compound Library | Drug Repurposing Compound Library | Neurotransmitter Receptor Compound Library | Anti-Pulmonary Fibrosis Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Substance P | Aprepitant | Senktide | Fezolinetant | Netupitant | Fosaprepitant dimeglumine | SB-222200 | Rolapitant | Talnetant | L-732138 | Saredutant | Maropitant | Casopitant mesylate | Neurokinin A TFA | H-Glu(OtBu)-OtBu hydrochloride | Pavinetant | Vofopitant dihydrochloride | Elinzanetant | Osanetant | Neurokinin B TFA | Vapreotide | Neurokinin A(4-10) TFA | Hemokinin 1 (mouse) | Men 10376 TFA | NKP608 | Spantide I | Substance P(1-7) TFA | Fosnetupitant
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
