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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2748337-86-0
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥1200.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥3000.0 |
| 规格： | 10 mg | 产品价格： | ￥4900.0 |
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AZ12601011
CAS No. : 2748337-86-0
MCE 国际站：AZ12601011
产品活性：AZ12601011 是一种具有口服活性的，选择性 TGFBR1 激酶抑制剂，IC50 为 18 nM，Kd 为 2.9 nM。AZ12601011 通过选择性的抑制 ALK4，TGFBR1 和 ALK7 来抑制 SMAD2 的磷酸化。AZ12601011 抑制乳腺肿瘤的生长。
研究领域：TGF-beta/Smad
作用靶点：TGF-β Receptor
In Vitro: AZ12601011 (0.01-10 μM; for 20 minutes) completely inhibits Phosphorylation of SMAD2 .
AZ12601011 (0.01 µM-10 µM) inhibits the activity of ALK4, ALK7 and TGFBR1 .
AZ12601011 inhibits 4T1 cells growth in vitro (IC50=0.4µM) .
In Vivo: AZ12601011 (50mg/kg; oral gavage; twice daily; for 25 days) inhibits tumour growth and metastasis in vivo.
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文献和实验5+YiLLj4HREBXstjztk7uH3PDncf2sPhxRlMq6wGF+vZ2OlE8VGoBH85gWn/XYBn2ck48eAqDu+xwjbrU7h2Zz2aZ3fD6YWWeBFuzJv2yfAMMyYBFj4y5r7yqpgAE0jPBFRyolzbpihAeo1X9z5K2o2YlqOUxRTN25rQLQ+8+x4oVfFzvgFHklZM2raEadaIsxjVfI0wedUizB5fB7r8yR8TTr6mQAL8FlQgbB6KCTABJiAfgWD8ev0cIrh
: 95% 1.5 mmol/L 乙酸铵，5% 乙腈，0.1% 甲酸。 ( 5 ) 溶融石英：100 μm ID X 360 μm OD ( Polymicro Technologies， Phoenix, AZ ) 。 ( 6 ) 反相装填材料：Zorbax Eclipse XDB- C18 5 μm ( Agilent Technologies， PaloAlto ， CA )。 ( 7 ) 阳离子交换装填材料：Poly SulfoethylA ( PolyLC 公司
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