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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1374996-60-7
- 规格：
10 mM * 1 mL/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3080.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2800.0 |
| 规格： | 10 mg | 产品价格： | ￥4800.0 |
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KP372-1
CAS No. : 1374996-60-7
MCE 国际站：KP372-1
产品活性：KP372-1是一种 Akt 抑制剂，能抑制癌细胞增殖并诱导细胞凋亡和失巢凋亡。KP372-1 也是一种 NQO1 氧化还原循环剂，通过产生活性氧 (ROS) 来引起 DNA 损伤 (包括 DNA 断裂)。KP372-1 能有效降低体内肿瘤生长，可用于癌症的研究 (如头颈部鳞状细胞癌和胰腺癌)。
研究领域：PI3K/Akt/mTOR | Metabolic Enzyme/Protease | Immunology/Inflammation | NF-κB | Apoptosis
作用靶点：Akt | Reactive Oxygen Species | Apoptosis
In Vitro: KP372-1 (0.0625, 0.125, 0.25, 0.5, 1.0 μM; 48 h) inhibits growth of JMARc42 and Tu167c2 cells with IC50s of 200 and 100 nM, respectively.
?KP372-1 (125 nM; 24 h) induces Tu167c2 cells apoptosis and induces anoikis in the JMARc42 cells.
?KP372-1 (125 nM; 30 min) blocks Akt, thereby decreasing the phosphorylation of the S6 ribosomal protein in both Tu167 and JMAR cells.
?KP372-1 (0.250, 0.5, 1.0 μM; 30 min) inhibits Akt kinase activity with an IC50 of 250 nM in JMAR cells.
In Vivo: KP372-1(10, 20 mg/kg; i.v.; single daily for 33 days) induces NADH oxidation and impairs tumor growth in vivo without apparent toxicity.
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文献和实验[/img] 点击GO后显示 [img]file:///C:/Documents%20and%20Settings/Administrator/Application%20Data/Tencent/Users/270756706/QQ/WinTemp/RichOle/~%7BH]~4MD6R67KP$]7R%7B%60~7E.jpg[/img] 这时候我是不是选择 [img]file:///C:/Documents%20and%20
去磷酸化而失活; 最近发现KP372-1能够抑制甲状腺癌细胞中Akt的活化以及细胞增殖诱导细胞凋亡. p70S6K是PI3K-Akt信号通路的另一可行性靶点, 免疫 抑制剂Rapamycin(RPM)广泛应用于临床器官移植中, 研究发现, RPM能够使p70S6K去磷酸化而抑制该激酶的活性, 从而抑制肿瘤细胞的生长, 目前已经在多种PTEN突变和/或PI3K-Akt通路活性上调的人类肿瘤细胞系中观察到RPM的选择性抗肿瘤活性[. 2. 反义策略 用基于质粒的反义载体进行
至400KP，调节载气压力至分析条件.打开色谱主机电源，参照实验条件分别设定进样口温度（INJ），检测器温度（DET）,柱温箱温度(COL),若用户加装了毛细管进样口，则进样口温度需设定AUX1或AUX2. 同时打开工作站电源，进入分析窗口。 4．按System键，仪器开始升温，待温度达到设定后，调节氢气流量阀至60KP左右，调节空气流量阀至45KP左右，然后按住排空键进行点火，确认是否点火成功。此时应注意检查检测器的选择（相应按键为DET#）是否正确，如检测器开关此时应处于ON的状态，观察极性
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