BCL2L1; BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52; BCL2 like 1
Category
Regulation of Apoptosis; Inhibition of Apoptosis; Mitochondrial Control of Apoptosis; B Cell Receptor Signaling
Background
BCL2L1/Bcl-xL (BCL2 like 1) prevents apoptosis through two different mechanisms: heterodimerization with an apoptotic protein inhibits its apoptotic effect and formation of mitochondrial outer membrane pores help maintain a normal membrane state under stressful conditions. Bcl-xL is phosphorylated by JNK following treatment with microtubule-damaging agents such as paclitaxel, vinblastine and nocodazole.