Human IL-4

Recombinant Human IL-4

产品详情

产品编号：200-04
产品描述：

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.

Source:E.coli

 

Synonyms:BCGF, BCDF, B cell stimulating factor (BSF-1)

 

AA Sequence:MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS

 

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

 

Biological Activity:The ED₅₀ as determined by the dose-dependent stimulation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁶ units/mg. 

 

Calculated Molecular Weight:15.1 kDa

 

Accession Number:P05112

 

Gene ID:3565

 

crossreactivity:
Bacteria, Chicken, Human , Human + Mouse, Leech, Mouse, N/A, Rabbit, Rat
Research Interest
 Immune System  Inflammation  Stem Cells & Differentiation  Allergy  Transplantation  Apoptosis  Cancer  Cell Culture
References
PubMed
SDS
Product Line

Country Of Origin: USA

Not for human use.