供应Hepatotoxicity library（造血毒性化

Hepatoma Cell Cultures as In Vitro Models for Hepatotoxicity

for the cytotoxicity of many xenobiotics. It has been suggested that hepatoma cell lines may provide an appropriate in vitro model for the assessment of likely hepatotoxicity in vivo. It should be noted, however, that the usefulness of such systems largely depends

Evaluation of Drug Metabolism, DrugDrug Interactions, and In Vitro Hepatotoxicity with Cryopreserved Human Hepatocytes

Human-based in vitro hepatic experimental systems are now used routinely in drug development. The initial concept of the use of human-based in vitro systems is based on the known species–species differences in drug properties. Human-specific

Assessment of Hepatotoxicity Potential of Drug Candidate Molecules Including Kinase Inhibitors by Hepatocyte Imaging Assay Technology and Bile Flux Im

molecule inhibitors of kinases are crucial in identifying new molecules with sufficient therapeutic window for clinical development. Failure or attrition of drug candidates in late-stage pipelines due to hepatotoxicity is a significant challenge in the drug