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- 详细信息
- 文献和实验
- 技术资料
- 保质期：
12个月
- 英文名：
Reserpine
- 供应商：
上海汇谱仪器有限公司
- CAS号：
50-55-5
- 规格：
250 mg
概述
- 产品名称
Reserpine - 描述
Irreversible vesicular monoamine transporter (VMAT2) antagonist - 生物学描述
Irreversible vesicular monoamine transporter (VMAT2) antagonist. Long-lasting bioamine depleter. Prevents bioamine transport into synaptic vesicles and chromaffin granules. Depletes biogenic amine stores. Antihypertensive and antipsychotic. - 纯度
> 98%
性能
- 化学名称
(3β,16β,17α,18β,20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester - 分子量
608.68 - 化学结构
- 分子式
C33H40N2O9 - CAS编号
50-55-5 - 存放说明
Store at Room Temperature. The product can be stored for up to 12 months. - 溶解度概述
Soluble in DMSO to 100 mM - 处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- 来源
Synthetic
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文献和实验Rauwolfia serpentina holds an important position in the pharmaceutical world because of its immense anti-hypertensive properties resulting from the presence of reserpine in the oleoresin fraction of the roots
Drug Effects on Behaviors Maintained by Electrical Brain Stimulation
). An immediate convergence with the coincidentally emerging field of psychopharmacology was achieved by Olds, who described for the first time the now classical finding that chlorpromazine and reserpine attenuate ICSS behavior (Olds et al., 1956 148 ).
从实竹桃科的印度萝芙木（Rauvolfia serPenti-na）根部提取出来的物质，有降血压和镇静作用，约包括 8种生物碱。利血平（ reserpine）是其代表。主要药理作用是对中枢神经系统的安定作用，以及对植物神经系统。特别对交感神经系统的抑制或者阻断作用。利用这种安定作用和条件回避反应抑制作用可作精神病的治疗药物使用，使释放出肾腺能神经的递质，而作为其结果的肾脏能神经的兴奋传递受到阻断，故可作降压剂使用。
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