CP21R7 is a potent and selective GSK-3β inhibitor.
信号通路
PI3K/Akt/mTOR
靶点
GSK-3β
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IC50
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体外研究
CP21R7 can inhibitor enhances the induction of KDR+precursors prior to vascular commitment. Cp21R7 compound induced the highest luciferase activity at a concentration of 3μM. Immunofluorescence staining revealed that CP21 significantly increased total levels of intracellular catenin. Activation of WNT signaling via GSK3 inhibition with CP21 induced commitment of hPSCs towards mesoderm.
体内研究
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临床实验
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特征
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相关实验数据(此数据来自于公开文献,信裕生物并不保证其有效性):
酶活性检测实验
方法
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细胞实验
细胞系
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浓度
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处理时间
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方法
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动物实验
动物模型
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配制
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剂量
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给药方式
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参考文献: 1. Christoph Patsch et al. Nat Cell Biol, 2015 Aug, 17(8), 994-1003.
包装清单: