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HIF-1 beta Recombinant Rabbit

mAb(bsm-52092R)-50ul/100ul
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  • ￥1400 - 2500
  • Bioss已认证
  • bsm-52092R
  • 2025年10月16日
  • 产品信息以Bioss网站为准
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      50ul/100ul

    规格：50ul产品价格：￥1400.0
    规格：100ul产品价格：￥2500.0
    产品编号bsm-52092R
    英文名称HIF-1 beta Recombinant Rabbit mAb
    中文名称缺氧诱导因子1β/HIF-1β重组兔单抗
    英文别名HIF1 beta; ARNT1; ARNT; HIF 1 beta; HIF-1 beta; ARNT protein; Aryl Hydrocarbon Receptor Nuclear Translocator; Dioxin Receptor; Dioxin receptor nuclear translocator; Drnt; HIF 1 beta; HIF 1beta; HIF1B; HIF1beta; Hypoxia Inducible Factor 1; Hypoxia inducible factor 1 beta; Tango; ARNT_HUMAN; Class E basic helix-loop-helix protein 2; bHLHe2; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta; HIF-1 β; HIF1-β; HIF 1-β; HIF-1-β; HIF 1 β; HIF1β; HIF1 β; HIF1-β; HIF 1β.
    产品应用WB=1:500-2000, IHC-P=1:50-200, IHC-F=1:50-200, IF=1:50-200, ICC/IF=1:50-200

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human
    抗体来源Rabbit
    免疫原A synthesized peptide derived from human HIF 1 beta
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Recombinant
    理论分子量87 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Response to hypoxia

    Cancer > Invasion/microenvironment > Hypoxia > HIF

    Cardiovascular > Hypoxia > HIF

    Epigenetics and Nuclear Signaling > Cardiovascular/Immune > Hypoxia > HIF

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > HLH

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Nucleotide metabolism

    Metabolism > Pathways and Processes > Metabolism processes > Hypoxia

    亚基Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interacts with NOCA7. Heterodimer with HIF1A.
    亚细胞定位Nucleus.
    相似性Contains 1 bHLH (basic helix-loop-helix) domain.
    Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 2 PAS (PER-ARNT-SIM) domains.
    功能Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:50-200}
    {IHC-F}{1:50-200}
    {IF}{1:50-200}
    {ICC/IF}{1:50-200}

     

    产品细节图片1
    4% P‌‌araformaldehyde-fixed HepG2 (H) cell; Triton X-100 at r.t. for 20 min; Antibody incubation with (HIF-1 beta) monoclonal Antibody, unconjugated (bsm-52092R) 1:100, 90 min at 37°C; followed by conjugated Goat Anti-Rabbit IgG antibody (green, bs-40295G-FITC) at 37°C for 90 min, DAPI (blue, C02-04002) was used to stain the cell nuclei. PBS instead of the primary antibody was used as the blank control.
    产品细节图片2
    25 ug total protein per lane of various lysates (see on figure) probed with HIF-1 beta monoclonal antibody, unconjugated (bsm-52092R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
    产品细节图片3
    P‌‌araformaldehyde-fixed, paraffin embedded Human testicles; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ARNT/HIF1 beta Monoclonal Antibody, Unconjugated(bsm-52092R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    产品细节图片4
    P‌‌araformaldehyde-fixed, paraffin embedded Human colon; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ARNT/HIF1 beta Monoclonal Antibody, Unconjugated(bsm-52092R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    产品细节图片5
    P‌‌araformaldehyde-fixed, paraffin embedded Human placenta; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ARNT/HIF1 beta Monoclonal Antibody, Unconjugated(bsm-52092R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    产品细节图片6
    P‌‌araformaldehyde-fixed, paraffin embedded Human uterus; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ARNT/HIF1 beta Monoclonal Antibody, Unconjugated(bsm-52092R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    产品细节图片7
    P‌‌araformaldehyde-fixed, paraffin embedded Human breast cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ARNT/HIF1 beta Monoclonal Antibody, Unconjugated(bsm-52092R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.

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