- ￥5832.53
- nsjbio
- V3327SAF-100UG
- 2025年11月24日
- Mouse
- Human. Other species not tested.
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Purified recombinant human EGFR was used as the immunogen for the EGF Receptor antibody.
- 亚型：
Mouse IgG1
- 克隆性：
单克隆
- 适应物种：
Human. Other species not tested.
- 宿主：
Mouse
- 规格：
100 ug
Primary antibody
纯化方法：
Purified
通用信息：
1 mg/ml in 1X PBS; BSA free, sodium azide free
产品描述：
Epidermal growth factor receptor (EGFR) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha. Upon activation by its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to an active homodimer. In addition to forming homodimers after ligand binding, EGFR may pair with another member of the ErbB receptor family, such as ErbB2/Her2/neu, to create an activated heterodimer. EGFR dimerization stimulates its intrinsic intracellular protein-tyrosine kinase activity. As a result, autophosphorylation of several tyrosine (Y) residues in the C-terminal domain of EGFR occurs. This autophosphorylation elicits downstream activation and signaling by several other proteins that associate with the phosphorylated tyrosines through their own phosphotyrosine-binding SH2 domains. These downstream signaling proteins initiate several signal transduction cascades, principally the MAPK, Akt and JNK pathways, leading to DNA synthesis and cell proliferation. [Wiki]
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文献和实验Assays to Monitor Degradation of the EGF Receptor
to conduct receptor downregulation assays are described. Monitoring of ubiquitination and degradation of the EGFR subsequent to stimulation with the receptor ligand EGF is described. Finally, protocols to quantitatively measure degradation of the EGFR
A Historical Perspective of the EGF Receptor and Related Systems
and physiological role that EGF plays during development and in adult animals led to the identification of its receptor (EGFR) as well as the other members of the EGF family of growth factors and their receptors. In this chapter we provide a historical overview
Motility Signaled From the EGF Receptor and Related Systems
Cell motility is now recognized as central to many biological processes. Growth factors, such as those that activate the epidermal growth factor receptor (EGFR), drive biochemically and biologically distinct subsets of migration critical
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