EGF Receptor / EGFR 抗体 [GFR/17

EGF Receptor / EGFR 抗体 [GFR/1708]，EGF Receptor / EGFR Antibody [GFR/1708]，EGF Receptor / EGFR 抗体 [GFR/1708],EGF Receptor / EGFR Antibody [GFR/1708]

产品名称：EGF Receptor / EGFR 抗体 [GFR/1708]-EGF Receptor / EGFR Antibody [GFR/1708]

产品货号：PSI-33-691-100ug

产品规格：100ug

背景资料：Epidermal growth factor receptor (EGFR) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha. Upon activation by its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to an active homodimer. In addition to forming homodimers after ligand binding, EGFR may pair with another member of the ErbB receptor family, such as ErbB2/Her2/neu, to create an activated heterodimer. EGFR dimerization stimulates its intrinsic intracellular protein-tyrosine kinase activity. As a result, autophosphorylation of several tyrosine (Y) residues in the C-terminal domain of EGFR occurs. This autophosphorylation elicits downstream activation and signaling by several other proteins that associate with the phosphorylated tyrosines through their own phosphotyrosine-binding SH2 domains. These downstream signaling proteins initiate several signal transduction cascades, principally the MAPK, Akt and JNK pathways, leading to DNA synthesis and cell proliferation. [Wiki]

保存建议：EGF Receptor / EGFR 抗体 [GFR/1708]-EGF Receptor / EGFR Antibody [GFR/1708]Aliquot and Store at 2-8℃

应用类型：WB, IF, Flow, IHC-P

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