- ￥5832.53
- nsjbio
- V2930IHC-7ML
- 2025年07月11日
- Mouse
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A recombinant protein corresponding to residues 1-181 from the human protein was used as the immunogen for the Wilms Tumor 1 antibody.
- 亚型：
Mouse IgG1, kappa
- 克隆性：
单克隆
- 适应物种：
Human
- 宿主：
Mouse
- 规格：
7 ml
Primary antibody
纯化方法：
Purified
通用信息：
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
产品描述：
Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm s tumors. WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas.
联系方式：
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官方售后：400-965-8633
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文献和实验Comparative Genomic Hybridization of Wilms tumor
Cytogenetic analysis of solid tumors including Wilms’ tumor is challenging due to poor chromosome morphology, complexity of abnormalities, and to the possibility of stromal cell overgrowth in tissue culture. Molecular cytogenetic techniques
Wilms Tumor as a Model for Cancer Biology
Wilms’ tumor of the kidney (WT) is the most common solid tumor of childhood, and it was first described in detail by Max Wilms’ in 1899. WT is a paradigm of childhood cancer, because it has served as a model from four distinct perspectives
Mutational Analysis of the Wilms' Tumor (WTI) Gene
Mutations of the Wilms’ tumor (WT1) gene have been shown to underlie a proportion of cases of Wilms’ tumor, an embryonal kidney cancer occurring mainly in childhood. The WTl gene comprtses ten exons spanning approx 50 kb of genomrc DNA
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