• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Wilms Tumor as a Model for Cancer Biology

        互联网

        620
        Wilms’ tumor of the kidney (WT) is the most common solid tumor of childhood, and it was first described in detail by Max Wilms’ in 1899. WT is a paradigm of childhood cancer, because it has served as a model from four distinct perspectives. First, it was one of three tumors used by Knudson in the early 1970s as a model for understanding the epidemiology of childhood cancer. Second, WT has played a key role is the molecular biology of childhood cancer. WT was one of the first examples in which a tumor suppressor gene was mapped by somatic genetic alterations in the tumors, compared to normal tissues, i.e., somatic cell gene mapping. Third, WT was the tumor in which abnormal imprinting in cancer was discovered. As such, it has been a model for epigenetic alterations in cancer. Finally, WT is a model for understanding the pathology of childhood cancer. Pediatric solid tumors, unlike adult malignancies, typically reflect normal developmental stages of organogenesis. As such, Wilms’ tumor has served as a developmental paradigm for nephrogenesis. The purpose of this chapter is to describe the evolution of WT as a model for cancer from each of these perspectives, and then to synthesize them in a unifying view that hopefully provides novel insights into the mechanism of cancer in general.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序