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67469-57-2
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GBR 12783
CAS No. : 67469-57-2
MCE 国际站：GBR 12783
产品活性：GBR 12783 是一种特异性，有效且选择性的多巴胺摄取抑制剂，可抑制大鼠和小鼠纹状体突触小体对 [3H] 多巴胺 ([3H]dopamine) 的摄取，IC50 分别为 1.8 nM 和 1.2 nM。GBR 12783 还可改善大鼠记忆力并增加海马通路乙酰胆碱的释放。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Dopamine Receptor
In Vivo: GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.
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文献和实验Chemokine control of HIV-1 infection
hetero-dimerization of the GBR1 and GBR2 receptors 8 . The interaction between GBR1 and GRB2 seems to be essential for the activation of potassium channels. One possibility is that the protective effect of CCR2V64I
Uptake and Release of Neurotransmitters
and [3H]GBR 12935 to rat and bovine striata. Membr. Biochem. 10:129‐144. Eshleman, A.J., Henningsen, R.A., Neve, K.A., and Janowsky, A. 1994. Release of dopamine via the human
Algorithm for Inference of Genetic Network Architectures, Pacific Symposium on Biocomputing, 3:18-29. 57• Ji X, Yuan Y, Li-Ling J, Li Y and Sun Z. 2004. HMMGEP: clustering gene expression data using hidden Markov models. Bioinformatics . 58• Kerr MK
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