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- ￥1375 - 5000
- Leading Biology
- AMM02538G
- 美国
- 2025年10月03日
- WB
- Mouse
- H
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- 文献和实验
- 技术资料
- 靶点：
E3 ubiquitin-protein ligase BRE1A, BRE1-A, hBRE1, 632-, RING finger protein 20, RNF20, BRE1A
- 浓度：
Affinity Purification
- 应用范围：
WB
- 宿主：
Mouse
- 适应物种：
H
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 克隆性：
Monoclonal
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 免疫原：
This RNF20 antibody is generated from a mouse immunized with a recombinant protein of human RNF20.
- 规格：
400 µl/200 µl/100 µl/50 µl
| 规格： | 400 µl | 产品价格： | ￥5000.0 |
|---|---|---|---|
| 规格： | 200 µl | 产品价格： | ￥3250.0 |
| 规格： | 100 µl | 产品价格： | ￥2250.0 |
| 规格： | 50 µl | 产品价格： | ￥1375.0 |
细胞定位：Nucleus
功能：Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
总结：Tissue Location: Expressed in the normal brain and also in malignant gliomas (at protein level).
稀释方法：WB--1:2000
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文献和实验determinant，抗原决定簇 ADA：adenosine deaminase，腺苷脱氨酶 ADCC：antibody-dependent cell-mediated cytotoxicity）抗体依赖细胞介导性细胞毒性 Adjuvant therapy：辅助治疗 AEL：acute erythrocytic leukemia，急性红白血病 AEoL：acute eosinophilic leukemia，急性嗜酸粒细胞白血病 aGVHD：acute graft versus host
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