- ￥1375 - 5000
- Leading Biology
- ApR05016G
- 美国
- 2025年09月29日
- WB
- Rabbit
- H, M, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 靶点：
Double-strand-break repair protein rad21 homolog, hHR21, Nuclear matrix protein 1, NXP-1, SCC1 homolog, RAD21, HR21, KIAA0078, NXP1
- 浓度：
Affinity Purification
- 应用范围：
WB
- 宿主：
Rabbit
- 适应物种：
H, M, Rat
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 克隆性：
Polyclonal
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 免疫原：
This RAD21 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 501-535 amino acids from human RAD21.
- 规格：
400 µl/200 µl/100 µl/50 µl
| 规格： | 400 µl | 产品价格： | ￥5000.0 |
|---|---|---|---|
| 规格： | 200 µl | 产品价格： | ￥3250.0 |
| 规格： | 100 µl | 产品价格： | ￥2250.0 |
| 规格： | 50 µl | 产品价格： | ￥1375.0 |
细胞定位：[Double-strand-break repair protein rad21 homolog]: Nucleus. Nucleus matrix Chromosome Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with chromatin (PubMed:11590136, PubMed:11073952). Before prophase, scattered along chromosome arms (PubMed:11073952). During prophase and prometaphase, most cohesins dissociate from the arms of condensing chromosome, possibly through PLK1-mediated phosphorylation (PubMed:11931760). A small amount of cohesin remains in centromeric regions and is removed from chromosomes only at the onset of anaphase. At anaphase, cleavage by separase/ESPL1 leads to the dissociation of cohesin from chromosomes and chromosome separation (PubMed:11073952, PubMed:11509732)
功能：[Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity).
总结：Tissue Location: Expressed in the gut (at protein level).
稀释方法：WB--1:2000
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文献和实验于研究。 性能参数 LIST OF ANTBODY PRODUCTS AP8401a BDP1 N-term Antibody AP8408b MEG2 C-term Antibody AP8451b PPP3CA C-term Antibody AP8449b CTDSP1 C-term Antibody AP8408a MEG2 N-term Antibody AP8451a PPP3CA N-term Antibody AP8449
Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins
of interest Plasmids (see Table 4.4.1 ): e.g., pEG202 (Fig. ), pSH18‐34 (Fig. ), pSH17‐4, pRFHM1 Yeast strain: e.g., EGY48 (ura3 trp1 his3 3LexA ‐operator‐LEU2 ; see Table
B 细胞内抗体产生新机制！两篇 Nature 重磅揭示染色质环挤压导致 V(D)J 重组和抗体类别转换重组
。同时，为了避免 AID 突变酶引发 CSR 相关的基因组重组，整个实验都在 AID 缺陷型细胞中进行。实验结果如下图所示：GRO-seq 结果显示，添加 anti-CD40 与 IL-4 诱导后的 B 细胞相比于静息 B 细胞在 Cγ1 与 Cε 处发生转录。HTGTS 结果显示，使用 iEμ–Ιμ 与 3′ IgHRR (HS4) 序列分别作为诱饵在诱导后的 B 细胞基因组上与 Cγ1 与 Cε 基因发生互作。而进一步的 ChIP-seq 也显示，黏着蛋白载体 NIPBL 与黏着蛋白亚基 RAD21
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