- $495
- Leading Biology
- United States
- APR08890G
- 2025年09月15日
- Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 克隆性：
单克隆
- 库存：
100
- 宿主：
Mouse
- 靶点：
A peptide corresponding to the amino acids 20-37 TQETFPPKYLHYDEETSH of human OPG was used to immunize mice. The specificity was tested on recombinant OPG by western blot analysis.
- 抗体名：
OCIF, OPG
- 规格：
50 μg
46kDa
细胞定位：
Antigen Cellular Localization: Secreted.
形式：
Liquid
参考文献：
Simonet W.S.,et al.Cell 89:309-319(1997). Yasuda H.,et al.Endocrinology 139:1329-1337(1998). Morinaga T.,et al.Eur. J. Biochem. 254:685-691(1998). Ota T.,et al.Nat. Genet. 36:40-45(2004). Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Osteoprotegerin / OPG antibody (aa20-37, clone 98A1071).
功能：
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
总结：
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
联系方式：
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
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文献和实验Notes on Making Rat x Y3 Monoclonal Antibody Producing Hybridomas
of one rat spleen (approx. 10**8 cells) together with 6 x 10**7 Y3/Ag1.2.3 per fusion (the other half of the spleen cells can be frozen as a backup in 90% FCS +10% DMS0). c) Try and keep all cells, PEG and medium components at 37 deg. C
标本。 2. 加20ul 1 N HC I ,盖紧，上下混匀。 2 － 8 ℃ 放置60± 2 分钟。 3. 加20ul 1 N NaOH, 盖紧，上下混匀。 4. 即用，或放-20/-70 ℃ 保存3 天。计算结果时乘 以稀释倍数 50 。 （ 注意：不同的标本E2F1 的水平可能有较大差异，请根据实际情况灵活掌握稀释度） 5. 细胞培养上清或组织匀浆 10 倍稀释 (410ul 的标本
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 人骨保护素 ( OPG )ELISA 试剂盒 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 OPG 单抗包被于酶标板上，标准品和样品中的 OPG与单抗结合，加入生物素化的抗人 OPG ，形成免疫复合物连接在板上，辣根过氧化物酶标记的 Streptavidin 与生物素结合
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