- $495
- Leading Biology
- United States
- APR13261G
- 2025年09月10日
- Goat
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 库存：
100
- 宿主：
Goat
- 抗体名：
SEMAF
- 规格：
0.1 mg
120615 Da
细胞定位：
Antigen Cellular Localization: Membrane; Single-pass type I membrane protein
形式：
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
参考文献：
High-resolution whole-genome association study of Parkinson disease Maraganore DM, de Andrade M, Lesnick TG, Strain KJ, Farrer MJ, Rocca WA, Pant PV, Frazer KA, Cox DR, Ballinger DG. Am J Hum Genet. 2005 Nov;77(5):685-93. Epub 2005 Sep 9. PMID: 16252231
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Semaphorin 5A antibody (internal region).
功能：
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
总结：
The immunizing peptide corresponds to a part of the extracellular domain.
联系方式：
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文献和实验To engineer or manipulate antibody or Fv-based molecules, isolation of the V region of the antibodies is necessary. A number of strategies can be adopted for amplification; one such approach is to use subgroup-specific oligonucleotides
Currently, the principal chemistries for the preparation of antibody–drug conjugates (ADC) target either lysines or cysteines for coupling cytotoxic drugs for delivery to target cells expressing tumor-specific antigens
Epitope Mapping by Region-Specified PCR Mutagenesis
This technique was developed for mapping of epitopes of monoclonal antibodies (MAb) at the amino acid sequence level; i.e., the identification of amino acids of an antigenic protein involved in specific interactions with each antibody
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