- $495
- Leading Biology
- United States
- APR12333G
- 2025年09月05日
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG2a Kappa
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 克隆性：
单克隆
- 库存：
100
- 宿主：
mouse
- 靶点：
HD (NP_002102, 81 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- 规格：
100 μg
347603 Da
细胞定位：
形式：
Clear, colorless solution in phosphate buffered saline, pH 7.2 .
参考文献：
Systemic energy homeostasis in Huntington's disease patients. Aziz NA, et al. J Neurol Neurosurg Psychiatry, 2010 Aug 14. PMID 20710011.Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease. Godin JD, et al. EMBO J, 2010 Jul 21. PMID 20531388.Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool. Olshina MA, et al. J Biol Chem, 2010 Jul 9. PMID 20444706.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder. Perlis RH, et al. Am J Psychiatry, 2010 May. PMID 20360314.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HD antibody (monoclonal) (M11).
功能：
总结：
Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.
联系方式：
生物商城：http://www.annoron.com
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官方售后：400-965-8633
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