- $495
- Leading Biology
- United States
- APR13330G
- 2025年08月28日
- Rabbit
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
472-499 aa
- 保存条件：
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 库存：
100
- 宿主：
Rabbit
- 抗体名：
BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
- 规格：
100 μl
55,85(actual) KDa
细胞定位：
Antigen Cellular Localization: Membrane; Single-pass type I membrane protein
形式：
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
参考文献：
Yamao T.,et al.Biochem. Biophys. Res. Commun. 231:61-67(1997). Kharitonenkov A.,et al.Nature 386:181-186(1997). Sano S.,et al.Biochem. J. 344:667-675(1999). Ota T.,et al.Nat. Genet. 36:40-45(2004). Deloukas P.,et al.Nature 414:865-871(2001).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Sirp α1 antibody.
功能：
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
总结：
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
联系方式：
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京经济技术开发区永昌中路4号院4号楼3层
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Xenoantibodies and Complement Activity Determinations in Pig-to-Primate Xenotransplantation
Based on the results from different studies, it is recommended to use multiple assays to fully monitor a peripheral antibody response in recipients of pig xenografts. In particular, the complement-dependent hemolytic assay (CH50) determines
，多偏居细胞一侧，染色质成粗块状沿核膜内面呈辐射状排列。胞质丰富，嗜碱性，核旁有一浅染区（图3－2）。电镜下，胞质内含有大量平行排列的粗面内质网和游离的多核糖体。发达的高尔基复合体和中心体位于核旁浅染区内（图3－8，3－9）。 图3－8 浆细胞超微结构模式图 图3-9 猴浆细胞电镜像×10250 粗面内质网 （白求恩医科大学尹昕、朱秀雄教授供图） 浆细胞具有合成、贮存与分泌抗体（antibody）即免疫球蛋白（immunoglobulin
链恒定区的是由不同的恒定区基因片段所编码。不同类Ig在理化性质及生物学功能上可有较大差异。 （2）亚类：同一类Ig中由于铰链区氨基酸组成和二硫键数目的差异，可分为不同的亚类，亚类间抗原性的差异要小于不同类之间的差异。目前已发现人的α重链有α1和α2两个亚类，分别与L链组成IgA1和IgA2。γ重链有4个亚类，但命名为IgG1、IgG2a、IgG2b和IgG3。IgM、IgD和IgG，目前尚未发现存在不同的亚类。Ig不同亚类也是由不同的恒定区基因片段编码。 2．免疫球蛋白的型和亚型
技术资料暂无技术资料 索取技术资料
