重组错配尿嘧啶DNA糖基化酶(Mug)现货供应

特别提示：包括重组错配尿嘧啶DNA糖基化酶(Mug)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组错配尿嘧啶DNA糖基化酶(Mug)
英文名称：Recombinant E. coli G/U Mismatch-Specific DNA Glycosylase/Mug
产品货号：JN1944
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目标蛋白包含序列(Met1-Arg168) of E.coli Mug.

Mug质量控制：＞95%(SEC-HPLC，还原性SDS-PAGE)

Mug制剂：液体

Mug保存：
收到后请置于-20℃以下，可保存长达6个月，避免反复冻融。

关于Mug：
E. coli Mismatch Uracil DNA Glycosylase (Mug protein) is an 18 kDa constitutively expressed protein which belongs to the TDG/mug DNA glycosylase family. It has been proposed that the Mug protein excises 3,N4-ethenocytosine and removes the uracil base from mismatches in the order of U:G>U:A, although the biological role remains unclear. Uracil bases in DNA can arise from deamination of cytosine giving rise to increased spontaneous mutations. The enzyme Uracil-N-Glycosylase removes uracil from the DNA leaving an AP site. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. It is required for DNA damage lesion repair in stationary-phase cells.

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