重组人IL-36α,158a.a.优惠促销

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产品名称：重组人IL-36α,158a.a.
英文名称：Recombinant Human Interleukin-36 alpha, 158a.a.
产品货号：GS4857
产品规格：2μg

分子量：Approximately 17.7kDa,a single non-glycosylated polypeptide chain containing 158 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.Studies showed IL-36α is mainly found in skin and lymphoid tissues,but also in fetal brain,trachea,stomach and intestine.Notably,IL-36 alpha is the only novel IL-1 family member expressed on T-cells.Recombinant human interleukin-36 alpha contains 158 amino acids residues which is a single non-glycosylated polypeptide and it is 30%a.a.identical to IL-1ra,and 27%,31%,36%,46%,57%and 28%a.a.identical to IL-1β,IL-36Ra/IL-1F5,IL-37/IL-1F7,IL-36β/IL-1F8,IL-36γ/IL-1F9 and IL-1F10.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The specific activity determined by its ability in a functional ELISA.Immobilized rHuIL-36α at 1μg/mL can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5 μg/mL.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in 2×PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuIL-36α,158a.a.as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF

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