An irreversible and potent EGFR/Neu inhibitor,inhibits EGFR phosphorylation
产品介绍
Afatinib(BIBW2992) is an irreversible EGFR/Neu inhibitor with an IC50 of 14 nM.Afatinib is a potent inhibitor of EGFR phosphorylation.Afatinib showed positive results in assays against a variety of human cancer cell lines,including A431,murine NIH-3T3 cells,and breast cancer cell line BT-474.
备注
Afatinib(BIBW2992) irreversibly inhibits EGFR/HER2 includingEGFR(wt),EGFR(L858R),EGFR(L858R/T790M) and HER2 withIC50of 0.5 nM,0.4 nM,10 nM and 14 nM,respectively;100-fold more active against Gefitinib-resistant L858R-T790M E