重组小鼠IL-6北京厂家

特别提示：包括重组小鼠IL-6在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组小鼠IL-6
英文名称：Recombinant Murine Interleukin-6
产品货号：GS4473
产品规格：2μg

分子量：Approximately 21.7kDa,a single non-glycosylated polypeptide chain containing 188 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-6(IL-6)encoded by the IL-6 gene,acts as both a pro-inflammatory and anti-inflammatory cytokine.It is secreted by T cells and macrophages to stimulate immune response.It plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation.It also induces myeloma and plasmacytoma growth and induces nerve cells differentiation acts on B-cells,T-cells,hepatocytes,hematopoietic progenitor cells and cells of the CNS.The mouse IL-6 is a single non-glycosylated polypeptide chain containing 187 amino acids and it signals through a cell-surface type I cytokine receptor complex consisting of the ligand-binding IL-6Rα chain(CD126),and the signal- transducing component gp130(also called CD130).The mouse IL-6 shares 40%and 85%a.a.sequence identity with human and rat IL-6 and it is equally active on human and rat cells.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is less than 0.02ng/ml,corresponding to a specific activity of>5×107 IU/mg.
成分	Lyophilized from a 0.2μmfiltered solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rMuIL-6 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT

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