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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
JAK2/FLT3-IN-1
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2387765-27-5
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1023.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥994.0 |
| 规格： | 10 mg | 产品价格： | ￥1585.0 |
| 规格： | 25 mg | 产品价格： | ￥2395.0 |
| 规格： | 50 mg | 产品价格： | ￥4050.0 |
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JAK2/FLT3-IN-1
CAS No. : 2387765-27-5
MCE 国际站：JAK2/FLT3-IN-1
产品活性：JAK2/FLT3-IN-1 是一种口服有效的双重 JAK2/FLT3 抑制剂，对 JAK2，FLT3，JAK1 和 JAK3 的 IC50 分别为 0.7 nM，4 nM，26 nM 和 39 nM。JAK2/FLT3-IN-1 具有抗癌活性。
研究领域：Epigenetics | Protein Tyrosine Kinase/RTK | JAK/STAT Signaling | Stem Cell/Wnt | Apoptosis
In Vitro: JAK2/FLT3-IN-1 (0.008-1 μM; for 2 hours) down-regulates p-FLT3 in a dose-dependent manner.
JAK2/FLT3-IN-1 (5-100 nM; for 2 hours) has a dose-dependent effect on the induction of apoptosis in the MV4-11 cells.
JAK2/FLT3-IN-1 (5-100 nM; for 2 hours) strongly induces cell cycle arrest with a G1/G0 percentage of 85% at 100 nM in the MV4-11 cells.
In Vivo: JAK2/FLT3-IN-1 (30 and 60 mg/kg/day; p.o.; for 14 days) exhibits significant antitumor effects.
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文献和实验蛋白产品货号 基础培养基 RPMI-1640 RPMI-1640 RPMI-1640 RPMI-1640 DMEM-F12 penicillin-streptomycin penicillin 100U/ml, streptomycin 100μg/ml dFBS（v/v） - 0.2% 2% 2% - L-glutamine 2mM B-27
- 1% - - - - - - - - 2-Mercaptoethanol - 0.2% - - - - - - - - sodium selenium - - - - - - 14ng/ml - - - B-27（无insulin） - - 1× 1× - - - 1× 1× - B-27（含insulin） - - - - 1×
9.0 16.07-27.4618.2 7.65-17.6916.5 2-3 豚鼠 1.5 5.5(5.0-6.1) 54.555.3 22.8a1 6.4 a2 18.9 8.18.0 14.611
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