抗大鼠 Fx1A 血清 Anti Fx1A serum

Chen B, Guan X, Gunning WT, Ge Y, Gohara AF, Dworkin LD, Gong R. Negative modulation of B cell activation by melanocortin 1 receptor signaling protects against membranous nephropathy. J Am Soc Nephrol. 34:467-481, 2023. doi: 10.1681/ASN.2022050605. Epub 2022 Nov 29. PMID: 36446431. (Rats)

Gao S, Cui Z, Zhao MH. Complement C3a and C3a receptor activation mediates podocyte injuries in the mechanism of primary membranous nephropathy. J Am Soc Nephrol. Sep;33(9):1742-1756, 2022. Epub 2022 Jul 1. PMID: 35777783; PMCID: PMC9529185. (Rats)  Editorial: Kettritz R, Schreiber A. Complement is complimentary in membranous nephropathy. J Am Soc Nephrol. 33:1631-1633, 2022. PMID: 35831021; PMCID: PMC9529176.

Coyne MJ, Schultze AE, McCrann DJ 3rd, Murphy RE, Cross J, Strong-Townsend M, Drake C, Mack R. Evaluation of renal injury and function biomarkers, including symmetric dimethylarginine (SDMA), in the rat passive Heymann nephritis (PHN) model. PLoS One. 17:e0269085, 2022. PMID: 35622875; PMCID: PMC9140233.

Gao Y, Dai H, Zhang N, Jiang H, Zhang Z, Feng Z, Dong Z, Liu W, Liu F, Dong X, Zhao Q, Zhou X, Du J, Zhang N, Rui H, Liu B. The ameliorative effect of Mahuang fuzi and Shenzhuo decoction on membranous nephropathy of rodent model is associated with autophagy and Wnt/β-catenin pathway. Front Pharmacol. 13:820130, 2022. PMID: 35529432; PMCID: PMC9068930. (Rats)

Wang X, Liu J, Tian R, Zheng B, Li C, Huang L, Lu Z, Zhang J, Mao W, Liu B, Bao K, Xu P. Sanqi oral solution mitigates proteinuria in rat passive Heymann nephritis and blocks podocyte apoptosis via Nrf2/HO-1 Pathway. Front Pharmacol. 12:727874, 2021. PMID: 34867334; PMCID: PMC8640486. (Rats) Erratum in: Front Pharmacol. 13:905693, 2022. PMID: 34867334; PMCID: PMC8640486.

Zhou HS, Cui Z, Wang H, Gao TT, Wang L, Wu J, Xiong ZY, Hao J, Zhao MH. The therapeutic effects of human embryonic stem cells-derived immunity-and-matrix regulatory cells on membranous nephropathy. Stem Cell Res Ther. 13:240, 2022. PMID: 35672767; PMCID: PMC9172125. (Rats)

​Wang XH, Yang YN, Liang Y, Lang R, Zeng Q, Yan L, Yu RH, Wu CM. Structural modulation of gut microbiota during alleviation of experimental passive Heymann nephritis in rats by a traditional Chinese herbal formula. Biomed Pharmacother: 145:112475, 2022. (Rats)

Wang XH, Lang R, Zeng Q, Liang Y, Chen N, Ma ZZ, Yu RH. Jianpi Qushi Heluo formula alleviates renal damages in passive Heymann nephritis in rats by upregulating Parkin-mediated mitochondrial autophagy. Sci Rep. 11:18338, 2021. PMID: 34526554; PMCID: PMC8443625. (Rats)

Yin J, Lin J, Yu J, Wei X, Zhu B, Zhu C. Tetrandrine may treat membranous glomerulopathy via P13K/Akt signaling pathway regulation: therapeutic mechanism validation using Heymann nephritis rat model. Bioengineered. 12:6499-6515, 2021. PMID: 34463195 (Rats)

Fan K, Zeng L, Guo J, Xie S, Yu Y, Chen J, Cao J, Xiang Q, Zhang S, Luo Y, Deng Q, Zhou Q, Zhao Y, Hao L, Wang Z, Zhong L. Visualized podocyte-targeting and focused ultrasound responsive glucocorticoid nano-delivery system against immune-associated nephropathy without glucocorticoid side effect. Theranostics. 11:2670-2690, 2021. PMID: 33456566; PMCID: PMC7806481. (Rats)

Hu S, Han R, Chen L, Qin W, Xu X, Shi J, Zhu X, Zhang M, Zeng C, Tang Z, Bao H, Liu Z. Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes. J Exp Med. 218:e20192373, 2021. PMID: 33346797; PMCID: PMC7756252. (Rats).

Pisarek-Horowitz A, Fan X, Kumar S, Rasouly HM, Sharma R, Chen H, Coser K, Bluette CT, Hirenallur-Shanthappa D, Anderson SR, Yang H, Beck LH Jr, Bonegio RG, Henderson JM, Berasi SP, Salant DJ, Lu W. Loss of Roundabout Guidance Receptor 2 (Robo2) in podocytes protects adult mice from glomerular injury by maintaining podocyte foot process structure. Am J Pathol. 2020 Mar 20. pii: S0002-9440(20)30024-9. [Epub ahead of print]. (PHN: Rats)  Boston University School of Medicine, Boston Medical Center, Pfizer, Inc.
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Sun H, Olsen HS, Merigeon EY, So E, Burch E, Kinsey S, Papadimitriou JC, Drachenberg CB, Bentzen SM, Block DS, Strome SE, Zhang X: Recombinant human IgG1 based Fc multimers, with limited FcR bindng capacity, can effectively inhibit complement-mediated disease. J Autoimmun 84: 87-98, 2017. (rats) University of Maryland School of Medicine, Gliknik, Inc., Chengdu Military General Hospital China. 

Nassiirpour R, Homer BL, Mathur S, Li Y, Li Z, Brown T, Carraher D, Warneke J, Bailey S, Percival K, O'Neil SP, Whiteley LO. Identification of promising urinary microRNA biomarkers in two rat models of glomerular injury. Toxicol Sci. 148 (1): 35-47, 2015 (rats) Pfizer Research and Development, Groton, CT. 

Lindskog Jonsson A, Granqvist A, Elvin J, Johansson ME, Haraldsson B, Nystrom: Effects of melanocortin 1 receptor agonists in experimental nephropathies. Plos one 9 e87816, 2014. (rats) (University of Gothenburg, Sweden). 

Lindskog A, Ebefors K, Johansson ME, Stefansson B, Granqvist A, Arnadottir M, Berg A-L, Nystrom J, Haraldsson B. Melanocortin 1 receptor agonists reduce proteinuria. J Am Soc Nephrol 21: 1290-1298, 2010. (rats). (University of Gothenburg, Sweden). Link

PTX-003: Anti-Thymocyte (Thy1) Serum:

Rufanova VA, Alexanian A, Ostendorf T, Bokenmeyer D, Prosser S, Miller B, Sorokin A: Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells. Can J Physiol Pharmacol 88:808-816, 2010. (Rats) (Medical College of Wisconsin, USA). Link

McIntosh LM, Barnes JL, Barnes VL, McDonald JR. Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis. Clin Exp Immunol 155:295-303, 2009. (rats) (Ospery Pharmaceuticals, Canada). 

Gullulu M, Akdag I, Kahvecioglu S, Filiz G and Savci V:  Aldosterone blockage in proliferative glomerulonephritis prevents not only fibrosis, but proliferation as well. Renal Failure 28:509-514 2006. (rats) Uludag University Medical School, Bursa, Turkey.