重组小鼠sTNF RII/TNFRSF1B

特别提示：包括重组小鼠sTNF RII/TNFRSF1B在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组小鼠sTNF RII/TNFRSF1B
英文名称：Recombinant Murine soluble Tumor Necrosis Factor Receptor Type II/TNFRSF1B
产品货号：GS4692
产品规格：5μg

分子量：Approximately 25.3kDa,a single non-glycosylated polypeptide chain containing 236 amino acids.
储存条件：冷冻（-20℃）

概述

Tumor Necrosis Factor Receptor-I(TNF RI,also known as p55/p60)and TNF RII(also known as p75/p80)are both high affinity receptors for TNF-alpha and -beta,potent mediators of multiple aspects of inflammatory immune responses.Both RI and RII are prototypic members of the TNF receptor superfamily and have been designated TNFRSF1A and TNFRSF1B,respectively.Whereas all cell types are thought to express TNF RI,TNF RII expression is limited primarily to hematopoietic cells and cells of the immune system.Most of the biological functions of TNF are mediated via TNF RI.Soluble forms of both TNF RI and TNF RII,generated as a result of proteolytic cleavage of the extracellular domains,have been detected in vivo in various biological fluids.The soluble TNF receptors can bind TNF with high affinity and functions as TNF antagonists.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by its ability to inhibit the TNF-α mediated cytotoxicity in the L-929 cells is less than 2μg/ml,corresponding to a specific activity of>500 IU/mg in the presence of 0.1ng/mL of rMuTNF-α.
成分	Lyophilized from a 0.2μmfiltered solution in PBS,pH 7.4.
内毒素	Less than 0.1 EU/μg of rMusTNF RII/TNFRSF1B as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	VPAQVVLTPY KPEPGYECQI SQEYYDRKAQ MCCAKCPPGQ YVKHFCNKTS DTVCADCEAS MYTQVWNQFR TCLSCSSSCT TDQVEIRACT KQQNRVCACE AGRYCALKTH SGSCRQCMRL SKCGPGFGVA SSRAPNGNVL CKACAPGTFS DTTSSTDVCR PHRICSILAI PGNASTDAVC APESPTLSAI PRTLYVSQPE PTRSQPLDQE PGPSQTPSIL TSLGSTPIIE QS

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