- ￥815
- 翌圣生物（Yeasen）
- 上海
- 90626ES08
- 2025年12月28日
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- 详细信息
- 文献和实验
- 技术资料
- 保质期：
有效期1年
- 保存条件：
-20℃至-80℃保存
- 英文名：
Recombinant Mouse sTNF RII/TNFRSF1B
- 库存：
大量
- 供应商：
翌圣生物科技（上海）股份有限公司
- 规格：
5μg
Product Information
| Product Name |
Cat# |
Size |
Price（¥） |
| Recombinant Mouse soluble Tumor Necrosis Factor Receptor Type II/TNFRSF1B (Mouse sTNF RII/TNFRSF1B) |
90626ES08 |
5 μg |
815 |
| 90626ES60 |
100 μg |
7,865 |
|
| 90626ES76 |
500 μg |
20,425 |
Product Description
Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa. The TNF receptor superfamily is comprised of structurally related receptors that bind to TNF-related ligands and regulate numerous processes such as immune cell activation and apoptosis. Receptors in this superfamily are characterized by the presence of a cysteine-rich region in their extracellular domain (ECD). Mouse TNF RII contains four cysteine-rich repeats in its ECD, which shares 58% and 84% amino acid sequence identity with the human and rat orthologs, respectively. Several receptors in the TNF superfamily also contain intracellular death domains (DDs) that recruit caspase-interacting proteins to initiate apoptosis upon ligand binding. Those receptors that lack DDs, like TNF RII, bind TNF Receptor-associated Factors, which transduce signals generated by activation of these receptors.
Product Properties
| Synonyms |
CD120b antigen; CD120b; Etanercept; p75 TNF receptor; p75TBPII; p75TNFR |
| Accession |
P25119 |
| GeneID |
21938 |
| Source |
E.coli-derived Mouse sTNF RII/TNFRSF1B, Val23-Gly258. |
| Molecular Weight |
Approximately 25.3 kDa. |
| AA Sequence |
VPAQVVLTPY KPEPGYECQI SQEYYDRKAQ MCCAKCPPGQ YVKHFCNKTS DTVCADCEAS MYTQVWNQFR TCLSCSSSCT TDQVEIRACT KQQNRVCACE AGRYCALKTH SGSCRQCMRL SKCGPGFGVA SSRAPNGNVL CKACAPGTFS DTTSSTDVCR PHRICSILAI PGNASTDAVC APESPTLSAI PRTLYVSQPE PTRSQPLDQE PGPSQTPSIL TSLGSTPIIE QSTKGG |
| Tag |
None |
| Physical Appearance |
Sterile Filtered White lyophilized (freeze-dried) powder. |
| Purity |
> 97% by SDS-PAGE and HPLC analyses. |
| Biological Activity |
The ED50 as determined by its ability to inhibit the TNF-α mediated cytotoxicity in the L-929 cells is less than 2 μg/mL, corresponding to a specific activity of > 500 IU/mg in the presence of 0.1 ng/mL of rMuTNF-α. Fully biologically active when compared to standard. |
| Endotoxin |
< 0.1 EU per 1μg of the protein by the LAL method. |
| Formulation |
Lyophilized from a 0.2 µm filtered solution in PBS, pH 7.4. |
| Reconstitution |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions. |
Shipping and Storage
The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Cautions
1. Avoid repeated freeze-thaw cycles.
2. For your safety and health, please wear lab coats and disposable gloves for operation.
3. For research use only!
HB220425
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