重组小鼠IL-36α(160a.a.)北京供应商

特别提示：包括重组小鼠IL-36α(160a.a.)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组小鼠IL-36α(160a.a.)
英文名称：Recombinant Murine Interleukin-36 alpha, 160a.a.
产品货号：GS4686
产品规格：2μg

分子量：Approximately 18.0kDa,a single non-glycosylated polypeptide chain containing 160 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36α is mainly found in skin and lymphoid tissues,but also in fetal brain,trachea,stomach and intestine.It is expressed by monocytes,B and T cells.Notably,IL-36 alpha is the only novel IL-1 family member expressed on T-cells.Recombinant murine interleukin-36 alpha contains 160 amino acids residues which is a single non-glycosylated polypeptide.Specifically,mouse IL-36α shares 83%a.a.sequence identity with rat IL-36α,54-60%with human,rabbit,equine and bovine IL-36α.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The specific activity determined by its ability in a functional ELISA.Immobilized rMuIL-36α at 1μg/mL can bind recombinant murine IL-1 Rrp2 with a range of 0.15-5 μg/mL.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4,5%trehalose.
内毒素	Less than 1 EU/μg of rMuIL-36α,160a.a.as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	MNKEKELRAA SPSLRHVQDL SSRVWILQNN ILTAVPRKEQ TVPVTITLLP CQYLDTLETN RGDPTYMGVQ RPMSCLFCTK DGEQPVLQLG EGNIMEMYNK KEPVKASLFY HKKSGTTSTF ESAAFPGWFI AVCSKGSCPL ILTQELGEIF ITDFEMIVVH

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