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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
142
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
Mundticin KS precursor
- 抗体名：
细菌素Mundticin KS多肽前体抗体
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
100ul/200ul
| 规格： | 100ul | 产品价格： | ¥1580.0 |
|---|---|---|---|
| 规格： | 200ul | 产品价格： | ¥2480.0 |
英文名称 : Mundticin KS precursor
中文名称 : 细菌素Mundticin KS多肽前体抗体
别 名 : mundticin KS precursor; mundticin L precursor; bacteriocin.
研究领域 : 细菌及病毒
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : mundticin KS, mundticin L
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
细胞定位 : 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human Mundticin KS precursor:
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Mundticin KS, a bacteriocin produced by Enterococcus mundtii NFRI 7393 isolated from grass silage in Thailand, is active against closely related lactic acid bacteria and the food-borne pathogen Listeria monocytogenes. In this study, biochemical and genetic characterization of mundticin KS was done. Mundticin KS was purified to homogeneity by ammonium sulfate precipitation, sequential ion-exchange chromatography, and solid-phase extraction. The gene cluster (mun locus) for mundticin KS production was cloned, and DNA sequencing revealed that the mun locus consists of three genes, designated munA, munB, and munC. The munA gene encodes a 58-amino-acid mundticin KS precursor, munB encodes a protein of 674 amino acids involved in translocation and processing of the bacteriocin, and munC encodes a mundticin KS immunity protein of 98 amino acids. Amino acid and nucleotide sequencing revealed the complete, unambiguous primary structure of mundticin KS; mundticin KS comprises a 43-amino-acid peptide with an amino acid sequence similar to that of mundticin ATO6 produced by E. mundtii ATO6. Mundticin KS and mundticin ATO6 are distinguished by the inversion of the last two amino acids at their respective C termini. These two mundticins were expressed in Escherichia coli as recombinant peptides and found to be different in activity against certain Lactobacillus strains, such as Lactobacillus plantarum and Lactobacillus curvatus. Mundticin KS was successfully expressed by transformation with the recombinant plasmid containing the mun locus in heterogeneous hosts such as E. faecium, L. curvatus, and Lactococcus lactis. Based on our results, the mun locus is located on a 50-kb plasmid, pML1, of E. mundtii NFRI 7393.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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文献和实验某些细菌能产生一种仅作用于有近缘关系的细菌的抗菌物质，称细菌素。细菌素为蛋白类物质，抗菌范围很窄，无治疗意义，但可用于细菌分型和流行病学调查。细菌素以生产菌而命名。大肠杆菌产生的细菌素称大肠菌素，绿脓杆菌产生的称绿脓菌素，霍乱弧菌产生的称弧菌素。
某菌株产生的对其他菌株显有颉颃活性的蛋白质类物质之总称。大肠杆菌（ Escherichia coli）产生的称为大肠杆菌素，绿脓杆菌（ Pseudomonas aer-uginosa＝ P． pyocyanea）产生的称为绿脓杆菌素，巨大芽孢杆菌（ Bacillus megaterium）产生的称为巨杆菌素。它们通常是对亲缘关系近的细菌表现活性，并通过吸附在敏感细菌上特异的受体上发挥作用。许多细菌素有很高的杀菌力，一个细菌素粒子约能杀死一个细菌。
多肽在体内表现出载体作用，可将目的药物吸附、粘贴、装载于载体上；而且多肽是一种生物活性物质，毒性作用较小，具有良好的生物相容性，可制成各种载体材料控制药物释放。因此，近年来将多肽作为药物载体、利用多肽对药物载体进行修饰及将多肽用于前体药物等领域逐渐引起人们的关注，具有良好的应用前景，也拓宽了多肽在医药领域的应用范围。 1.受体导向的多肽靶向药物载体 小片段多肽具有低毒性、靶向性、无免疫原性、良好的生物相容性等特点。研究已发现，肿瘤细胞表面会高表达多肽类受体，因此一些短肽可作为导向物，以配体
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