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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
江西江蓝纯生物试剂有限公司
- 库存:
176
- 克隆性:
单克隆
- 保质期:
1年
- 抗体英文名:
MPO/Myeloperoxidase
- 抗体名:
髓过氧化物酶抗体
- 适应物种:
人/动物/植物
- 应用范围:
WB,ELISA等
- 浓度:
1mg/ml
- 保存条件:
-20 °
- 规格:
100ul/200ul/50ul
| 规格: | 100ul | 产品价格: | ¥1580.0 |
|---|---|---|---|
| 规格: | 200ul | 产品价格: | ¥2480.0 |
| 规格: | 50ul | 产品价格: | ¥880.0 |
英文名称 : MPO/Myeloperoxidase
中文名称 : 髓过氧化物酶抗体
别 名 : Myeloperoxidase; MPO; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; EC 1.11.1.7; PERM_HUMAN.
研究领域 : 肿瘤 细胞生物 免疫学 激酶和磷酸酶 淋巴细胞
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human,
产品应用 : WB=1:500-2000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 84kDa
细胞定位 : 细胞浆
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human MPO/Myeloperoxidase:161-260/745
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008].
Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Subunit:
Tetramer of two light chains and two heavy chains.
Subcellular Location:
Lysosome.
DISEASE:
Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
Similarity:
Belongs to the peroxidase family. XPO subfamily.
SWISS:
P05164
Gene ID:
4353
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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文献和实验病例3:髓过氧化物酶缺乏 髓过氧化物酶缺乏症:(myeloperoxidase deficiency,MPO)是一种遗传性吞噬细胞内髓过氧化物酶缺陷的免疫缺陷病,该病罕见。多有家族史,自幼反复发生细菌或真菌感染[5,6]。MPO是吞噬细胞杀菌系统中另一酶系统当酶活性甚低时,使中性粒细胞完全缺乏MPO-H2O2-卤化物系统的杀菌活力,对化脓性细菌和真菌易感性增加。基因位于17q22-q23。无症状者不需治疗,有感染者应选用敏感抗生素。 研究表明,中性粒细胞和单核细胞MPO缺陷
系一种过氧化物酶,含在白血球和骨髓( Myelo)的嗜伊红细胞中。因显绿色所以也称绿过氧化物酶。可高度提纯精制出来。辅基用盐酸 -丙酮处理不与蛋白质分离,吸收带向长波侧移动,似具有与其它过氧化物酶不同的血红素。作用形式与辣根过氧化物酶相同,但活性弱。可氧化已纳入到白血球内的物质,起解毒作用。
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 人髓过氧化物酶 ( MPO )ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和唾液、尿液、生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 MPO 单抗包被于酶标板上,标准品和样品中的 MPO与单抗结合,加入生物素化的抗人 MPO ,形成
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