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- 文献和实验
- 技术资料
- 供应商:
江西江蓝纯生物试剂有限公司
- 库存:
109
- 克隆性:
单克隆
- 保质期:
1年
- 抗体英文名:
TIAF1
- 抗体名:
TGFB1诱导抗凋亡因子1抗体
- 适应物种:
人/动物/植物
- 应用范围:
WB,ELISA等
- 浓度:
1mg/ml
- 保存条件:
-20 °
- 规格:
100ul/200ul
| 规格: | 100ul | 产品价格: | ¥1580.0 |
|---|---|---|---|
| 规格: | 200ul | 产品价格: | ¥2480.0 |
英文名称 : TIAF1
中文名称 : TGFB1诱导抗凋亡因子1抗体
别 名 : MAJN; TGFB1 induced anti apoptotic factor 1 (12 kDa TGF beta1 induced antiapoptotic factor); 12 kDa TGF-beta-1-induced antiapoptotic factor; TGFB1 induced anti apoptotic factor 1; TGFB1-induced anti-apoptotic factor 1; TIAF1_HUMAN; MAJN; SPR210; MYO18A; MYSPDZ; TGFB1 induced anti apoptotic factor 1. 研究领域 : 细胞生物 信号转导 细胞凋亡 转录调节因子
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 12kDa
细胞定位 : 细胞核
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human TIAF1:34-115/115
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : TIAF-1 (TGF Beta 1-induced antiapoptotic factor 1), also known as MYO18A, MAJN or MYSPDZ, is a TGF Beta 1-induced anti-apoptotic factor that localizes to the nucleus and functions to inhibit the cytotoxic effects of TNF? TRADD and FADD. Two isoforms of mouse TIAF-1 exist and are designated MysPDZ-Alpha and MysPDZ-Beta. MysPDZ-Alpha consists of a KE-rich region, an N-terminal PDZ domain and a prevalent myosin homologous head region, while the MysPDZ-Beta isoform lacks the KE-rich region and PDZ domain. MysPDZ-Alpha is present in most tissues and is known to co-localize with the ER-Golgi complex and with membrane ruffles and filopodia. MysPDZ-Beta is expressed specifically in hematopoietic tissues and cell lines and shows dispersed localization in the cytoplasm.
Function:
This protein inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIP. It is involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.
Subcellular Location:
Nuclear
Tissue Specificity:
Not detectable in normal kidney and liver. Up-regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells.
SWISS:
O95411
Gene ID:
9220
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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