Esculin秦皮甲素,531-75-9

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Esculin

CAS No. : 531-75-9

MCE 国际站：Esculin

产品活性：Esculin 是一种荧光香豆素葡萄糖苷，是灰树皮的有效成分。Esculin 具有抗糖尿病作用，通过 MAPK 信号通路改善实验性糖尿病肾病 (DN) 的认知障碍，并发挥抗氧化应激和抗炎作用。Esculin 还具有抗癌、抗菌、抗病毒、神经保护、抗血栓和治疗眼部疾病的特性。

研究领域：MAPK/ERK Pathway

作用靶点：p38 MAPK

In Vitro: Esculin (100 μM; 2-8 h) has antiviral activity agasint White spot syndrome virus (WSSV) monomer in Litopenaeus vannamei larvae, with a safe concentration of 100 μM.
Esculin (200 μM, 400 μM, 600 μM; 4 h or 2 h) is a chemical protectant of red blood cells, protecting them from oxidative damage. Esculin inhibits the increase of markers of oxidative stress (such as protein and lipid oxidation) induced by Bioallethrin (HY-122376) (50-200 μM; 4 h or 2 h) in red blood cells and lymphocytes, and restores reduced free amino groups. The ratio of reduced glutathione to oxidized glutathione is also increased.

In Vivo: Esculin (5, 10, and 20 mg/kg; Intragastric administration, once daily for 2 days) protects mice model of ethanol-induced gastric injury. Esculin inhibits NF-κB activation, thereby reducing the expression of iNOS, TNF-α and IL-6. Esculin reduces histopathological damage in a dose-dependent manner.

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