BPN-15606 besylate,2436239-00-

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

BPN-15606 besylate

CAS No. : 2436239-00-6

MCE 国际站：BPN-15606 besylate

产品活性：BPN-15606 besylate 是一种高效的口服活性 γ-secretase 调节剂 (GSM)，可减弱 SHSY5Y 神经母细胞瘤细胞产生 Aβ42 和 Aβ40 的作用，IC₅₀ 值分别为 7 nM 和 17 nM。BPN-15606 besylate 可以降低大鼠和小鼠中枢神经系统中的 Aβ42 和 Aβ40 水平。BPN-15606 besylate 具有良好的 PK/PD 特性，包括生物利用度，半衰期和清除率。

研究领域：Neuronal Signaling  |  Stem Cell/Wnt

作用靶点：γ-secretase

In Vitro: BPN-15606 besylate (oral administration; 10 mg/kg, 25 mg/kg and 50 mg/kg; 7 days) shows excellent dose-dependent efficacy in both plasma and brain on lowering of Aβ42 and Aβ40 levels in mice.
BPN-15606 besylate (oral administration; 5 mg/kg, 25 mg/kg and 50 mg/kg; 9 days) dose-dependently reduces CSF on lowering of Aβ42 and Aβ40 levels in rats.
BPN-15606 besylate (oral administration; 25 mg/kg; single dose) shows a robust effect on both brain and plasma Aβ 42 and Aβ40 levels, which begins approximately 30–60 minutes following the single dose administration and lasted for ≥24 hours in C57BL/6 mice.

相关产品：DAPT  |  LY-411575  |  Compound E  |  YO-01027  |  RO4929097  |  Nirogacestat  |  Crenigacestat  |  Semagacestat  |  MK-0752  |  L-685458  |  BMS-906024  |  E 2012  |  Sulindac sulfide  |  Avagacestat  |  BPN-15606  |  MRK-560  |  BMS 299897  |  PF-06648671  |  SPL-707  |  Z-Ile-Leu-aldehyde  |  Begacestat  |  Itanapraced  |  LY900009  |  NGP555  |  ELN318463  |  Aβ42-IN-2  |  Fosciclopirox  |  gamma-secretase modulator 1 hydrochloride  |  gamma-secretase modulator 2  |  JNJ-40418677

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds