Danicopan,1903768-17-1

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Danicopan

CAS No. : 1903768-17-1

MCE 国际站：Danicopan

产品活性：Danicopan (ACH-4471) 是一种选择性的口服活性 factor D 抑制剂，对 factor D 具有高结合亲和力，其 K_d 值为 0.54 nM。Danicopan (ACH-4471) 可抑制补体 (APC) 活性的替代途径，具有阻断阵发性夜间血红蛋白尿 (PNH) 和非典型溶血性尿毒症综合征 (aHUS) 的补体替代途径的潜力。

研究领域：Immunology/Inflammation

作用靶点：Complement System

In Vitro: Danicopan (ACH-4471) inhibits the proteolytic activity of purified Factor D against its natural substrate Factor B in complex with C3b, blocking production of Bb fragment in a dose-dependent manner with an IC₅₀ value of 0.015 μM.
?Danicopan (ACH-4471) potently inhibits hemolysis with IC₅₀ values ranging from 0.0040 μM to 0.027 μM (IC₉₀ values from 0.015 μM to 0.11 μM).

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