ML753286,1699720-89-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

ML753286

CAS No. : 1699720-89-2

MCE 国际站：ML753286

产品活性：ML753286 是一种口服活性和选择性 BCRP (抗乳腺癌蛋白) 抑制剂，IC₅₀ 为 0.6 μM。 ML753286 在啮齿动物和人类肝脏 S9 组分中具有高渗透性和低至中等清除率，并且在不同物种中都具有血浆稳定性。

研究领域：Membrane Transporter/Ion Channel

作用靶点：BCRP

In Vitro: ML753286 has IC₅₀ values of >30, 0.6, and 39.0 μM for the inhibition of P-gp-, BCRP-, and OATP mediated transport, respectively.

In Vivo: ML753286 (25- or 50-mg/kg (PO); 10 or 20 mg/kg (IV); 0.083-24 hours) appears to completely inhibit Bcrp functions in rats at 25 mg/kg PO or at 20 mg/kg IV. The t_max values in plasma were 1.4, 4.0, and 4.1 hours in Bcrp KO rats, WT rats pre-administered 25-mg/kg ML753286, and WT rats pre-administered 50-mg/kg ML753286, respectively.

相关产品：Ko 143  |  Elacridar  |  CP-100356 hydrochloride  |  Fumitremorgin C  |  YHO-13351 free base  |  YHO-13177  |  KS176  |  PCI 29732  |  Efflux inhibitor-1  |  Zamicastat  |  (S)-ML753286  |  ML230  |  PD166326  |  3,7,2',4'-Tetramethoxy-5-hydroxyflavone  |  5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone  |  6,8-Diprenylnaringenin  |  ABCG2-IN-1  |  ABCG2-IN-2  |  Ac32Az19  |  Antitumor photosensitizer-4  |  CCTA-1523  |  FD 12-9  |  P-gp/BCRP-IN-1  |  P-gp/BCRP-IN-2  |  Triclabendazole sulfoxide  |  UR-MB108

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds