SA-1 Background Information The cohesion complex is a multi-protein structure that is required for cohesion of sister chromatids after DNA replication and may be involved in mitotic spindle pole assembly. The complex is composed of a heterodimer between SMC1 and SMC3, two proteins that are linked at their heads by Rad21, and an additional protein called SA-1 (stromal antigen 1). SA-1, also known as STAG1, is a 1258 amino acid component of the cohesion complex that interacts directly with Rad21. Localized to the nucleus, SA-1 associates with chromatin and, upon phosphorylation by Plk, dissociates from chromatin to allow proper chromosome separation during anaphase. SA-1, the human homolog of yeast Scc3p, is expressed in thymus, bone marrow and spleen and is 99% similar to its mouse counterpart.
SA-1 (F-3)
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SA-1 (F-3): sc-271976. Western blot analysis of SA-1 expression in HuT 78 whole cell lysate.