- 询价
- Cell Signaling Technology
- 3399
- USA
- 2025年07月16日
- W
- Rabbit
- H,M
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- 详细信息
- 技术资料
- 抗体英文名：
Phospho-M-CSF Receptor (Tyr699) Antibody
- 抗原：
synthetic peptide corresponding to residues around Tyr699 of human M-CSF receptor
- 应用范围：
W
- 宿主：
Rabbit
- 库存：
大量
- 适应物种：
H,M
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 供应商：
CST
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M | Endogenous | 175 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Phospho-M-CSF Receptor (Tyr699) Antibody detects endogenous levels of M-CSF receptor only when phosphorylated at Tyr699. The antibody may cross-react slightly with other activated tyrosine kinases including PDGF receptors. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues around Tyr699 of human M-CSF receptor. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from FDCP1/fms cells, untreated or M-CSF treated, using Phospho-M-CSF Receptor (Tyr699) Antibody (upper) or M-CSF Receptor Antibody #3152 (lower). |
| Background | Macrophage-colony stimulating factor (M-CSF, CSF-1) receptor is an integral membrane tyrosine kinase encoded by the c-fms proto-oncogene. M-CSF receptor is expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage. (1-3). Binding of M-CSF to its receptor induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins (4). There are at least five major tyrosine autophosphorylation sites. Tyr723 (Tyr721 in mouse) is located in the kinase insert (KI) region. Phosphorylated Tyr723 binds the p85 subunit of PI3 kinase as well as PLC-γ 2 (5). Phosphorylation of Tyr809 provides a docking site for Shc (5). Overactivation of this receptor can lead to a malignant phenotype in various cell systems (6). The activated M-CSF receptor has been shown to be a predictor of poor outcome in advanced epithelial ovarian carcinoma (7) and breast cancer (8). Phosphorylation of M-CSF receptor on Tyr669 was identified at Cell Signaling Technology (CST) using PhosphoScan®, CST's LC-MS/MS platform for phosphorylation site discovery, as well as in another publication (10). Autophosphorylation at Tyr699 in the kinase insert (KI) domain appears to provide a binding site for the Grb2 adaptor protein (9).
|
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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