- 询价
- Cell Signaling Technology
- 3763
- USA
- 2025年12月24日
- W, IP
- Rabbit
- H,M,R
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
IP3 Receptor Antibody
- 抗原：
synthetic peptide surrounding Met2750 of human IP3 receptor
- 应用范围：
W, IP
- 宿主：
Rabbit
- 库存：
大量
- 级别：
详见MSDS文件
- 适应物种：
H,M,R
- 供应商：
CST
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H M R | Endogenous | 320 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | IP3 Receptor Antibody detects endogenous levels of total IP3 receptor type 1 protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide surrounding Met2750 of human IP3 receptor. Antibodies are purified by protein A chromatography. Western Blotting
Western blot analysis of extracts from mouse and rat brain using IP3 Receptor Antibody. |
| Background | Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family and is located in the endoplasmic reticulum. IP3R functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3R1, 2, and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation (1). Four individual subunits homo- or hetero-oligomerize to form the receptor's functional channel (2). Phosphorylation of IP3R1 at Ser1756 by cyclic AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may be a mode of regulation for Ca2+ release (3,4). IP3R1-mediated Ca2+ release appears to have an effect on the induction of long term depression (LTD) in Purkinje cells (5). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验IP3受体是一种内质网通道蛋白, 由四个相对分子质量为260kDa的糖蛋白组成的四聚体。四个亚基组成一个跨膜的通道, 每个亚基都有IP3结合的部位, 当3～4个部位被IP3占据时, 受体复合物构象发生改变, 打开离子通道, 储藏在内质网中的Ca2 随即释放,进入胞质溶胶。
Aspects of CNS Lupus: Mouse Models of Anti-NMDA Receptor Antibody Mediated Reactivity
This chapter describes methods utilized in establishing a mouse model of neuropsychiatric lupus encompassing both cognitive and emotional dysfunction, and a model of the influence of maternal antibody on the developing brain. The antibody
Single-Cell Imaging Techniques for the Real-Time Detection of IP3 in Live Cells
Inositol 1,4,5-trisphosphate (IP3 ) is a ubiquitous second messenger, derived from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2 ) by enzymes of the phospholipase C (PLC) family. Binding of IP3 to its cognate receptor
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