- 询价
- Cell Signaling Technology
- 3713
- USA
- 2025年12月21日
- W
- Rabbit
- H,M,R,Mk
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体英文名：
TGF-β Receptor II (K105) Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding Lys105 (extracellular region) of human TGF-β receptor II
- 应用范围：
W
- 宿主：
Rabbit
- 保质期：
详见说明书
- 库存：
大量
- 适应物种：
H,M,R,Mk
- 级别：
详见MSDS文件
- 供应商：
CST
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R (Mk) | Endogenous | 70-80 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | TGF-β Receptor II (K105) Antibody detects endogenous levels of total TGF-β receptor II protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys105 (extracellular region) of human TGF-β receptor II. Antibodies were purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from HeLa cells, mock transfected or transfected with human TGF-β receptor II construct, using TGF-β Receptor II (K105) Antibody. Western Blotting
Western blot analysis of extracts from NCCIT, DLD-1 and Pys-2 cells using TGF-β Receptor II (K105) Antibody. |
| Background | Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis (1-4). TGF-β elicits signaling through three cell surface receptors: type I (RI), type II (RII) and type III (RIII). Type I and type II receptors are serine/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases (5). The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellular domain that binds TGF-β with high affinity but lacks a cytoplasmic signaling domain (6,7). Expression of the type III receptor can regulate TGF-β signaling through presentation of the ligand to the signaling complex. The only known direct TGF-β signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regulate target gene transcription (8,9).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Immunohistochemical Detection of Angiotensin II Receptor
for cell-specific localization of receptor expression within tissue. The resolution and sensitivity achieved with IHC is far greater than that obtained with classic autoradiography techniques although antireceptor antibody
The Detection of Antibodies to the Angiotensin II-Type 1 Receptor in Transplantation
The detection of auto-antibodies detection is a major aspect of patient’s immunomonitoring. Antibodies directed against the heart and kidney Angiotensin II type 1 receptor (AT1 R) play a major role in antibody mediated rejection after heart
11 Detection of TGF Type II Receptor Hotspot Mutations: The BAT-RII Assay
in the TGF-β pathway detected thus far is mutation of the type II receptor (RII) in colon cancers, particularly in tumors with defective mismatch repair or microsatellite instability (MSI) (3 –5 ). These RII mutations occur in a repetitive region of coding
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