- 询价
- Cell Signaling Technology
- 9682
- USA
- 2025年11月14日
- W
- Rabbit
- H,M,R,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
β-Amyloid (1-40 specific) Antibody
- 抗原：
synthetic peptide corresponding to residues at the carboxy terminus of human β-amyloid (1-40) peptide
- 应用范围：
W
- 宿主：
Rabbit
- 保质期：
详见说明书
- 适应物种：
H,M,R,Mk
- 库存：
大量
- 级别：
详见MSDS文件
- 供应商：
CST
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H (M) (R) (Mk) | Recombinant | 4 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | β-Amyloid (1-40 specific) Antibody recognizes the Aβ-40 isoform of the β-amyloid peptides. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues at the carboxy terminus of human β-amyloid (1-40) peptide. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of human Aβ-37, Aβ-38, Aβ-39, Aβ-40, and Aβ-42 peptides (10 ng) using β-Amyloid (1-40 specific) Antibody (upper) and β-Amyloid Antibody #2454 (lower). |
| Background | Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains the amyloid domain (Aβ), which can be released by a two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimer's disease (AD) (1). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (2-5). Phosphorylation at Thr668 (at a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell cycle-dependent and peaks during G2/M phase (4). APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation (5,6).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Evaluating Amyloid Beta (A) 1-40 Degradation by Capillary Electrophoresis
Here, we describe a capillary electrophoresis method for evaluating proteolysis of the amyloid beta peptide (Aβ) 1–40. This method is suitable for kinetic studies, demands little specialized equipment, and consumes only small
Effects of the β-Amyloid Peptide on Membrane Ion Permeability
Several lines of evidence suggest a role for membrane ion channels in the neurotoxic effects of the β-amyloid peptide (Aβ). This chapter describes the electrophysiological techniques that can be employed to isolate and record specific membrane
人β淀粉样蛋白1-40（Aβ1-40）酶联免疫分析（ELISA）
人β淀粉样蛋白1-40（Aβ1-40） 酶联免疫 分析（ELISA） 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本中β淀粉样蛋白1-40（Aβ1-40） 的 含量。 实验原理 ： 本试剂盒应用双抗体夹心法测定 标本 中 人β淀粉样蛋白1-40 （ A β 1-40 ） 水平。用纯化的 人β淀粉样蛋白1-40 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 β淀粉样蛋白1-40 抗原
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