- 询价
- Cell Signaling Technology
- 9568
- USA
- 2025年11月04日
- W, IP
- H
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- 详细信息
- 技术资料
- 抗体英文名：
NHERF2 (D3A5) Rabbit mAb
- 抗原：
synthetic peptide corresponding to residues near the carboxy terminus of human NHERF2 protein
- 应用范围：
W, IP
- 级别：
详见MSDS文件
- 库存：
大量
- 供应商：
CST
- 保质期：
详见说明书
- 适应物种：
H
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP | H | Endogenous | 46 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | NHERF2 (D3A5) Rabbit mAb recognizes endogenous levels of total NHERF2 protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human NHERF2 protein. Western Blotting
Western blot analysis of extracts from MCF7 and T-47D cells using NHERF2 (D3A5) Rabbit mAb. |
| Background | Na+ /H+ exchanger regulatory factor 2 (NHERF2) is one of four proteins in the NHERF protein family. It is closely related to NHERF1 and, like NHERF1, contains two PDZ domains and a C-terminal ezrin/radixin/moesin (ERM) binding domain (EBD). Along with the other members of this protein family, NHERF2 is abundantly present in the mammalian small intestine and colon where it plays a central role in trafficking, membrane retention, dimerization, and regulation of ion channels and membrane proteins (1). NHERF2 is a scaffolding protein that recruits membrane proteins to the apical membrane by tethering them to the apical cytoskeleton via its ERM domain (2). It has been shown that the NHERF proteins bind to the Na+ /H+ exchanger 3 (NHE3) in the brush border of intestinal epithelial cells. NHE3 accounts for the majority of neutral NaCl absorbtion and NHERF proteins play an essential role in NHE3 regulation (3). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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