- 询价
- Cell Signaling Technology
- 2179
- USA
- 2025年10月29日
- W, IP
- H,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
c-Cbl (C49H8) Rabbit mAb
- 抗原：
synthetic peptide corresponding to the sequence of human c-Cbl
- 应用范围：
W, IP
- 供应商：
CST
- 保质期：
详见说明书
- 适应物种：
H,Mk
- 库存：
大量
- 级别：
详见MSDS文件
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
40 ul (4 western blots)/100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 40 ul (4 western blots) | 产品价格： | ￥请询价 |
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP | H Mk | Endogenous | 120 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | c-Cbl (C49H8) Rabbit mAb detects endogenous levels of total c-Cbl protein. The antibody does not cross-react with Cbl-b or Cbl-c proteins. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human c-Cbl. Western Blotting
Western blot analysis of cell extracts from various cell types using c-Cbl (C49H8) Rabbit mAb. |
| Background | The c-Cbl proto-oncogene is a ubiquitously expressed cytoplasmic adaptor protein that is especially predominant in hematopoietic cells (1,2). c-Cbl is rapidly tyrosine-phosphorylated in response to stimulation of a variety of cell-surface receptors and becomes associated with a number of intracellular signaling molecules such as protein tyrosine kinases, phosphatidylinositol-3 kinase, Crk and 14-3-3 proteins (3,4). c-Cbl possesses a highly conserved amino-terminal phosphotyrosine binding domain (TKB) and a C3HC4 RING finger motif. The TKB recognizes phosphorylated tyrosines on activated receptor tyrosine kinases (RTKs) as well as other nonreceptor tyrosine kinases. The RING finger motif recruits ubiquitin-conjugating enzymes. These two domains are primarily responsible for the ubiquitin ligase activity of c-Cbl and downregulation of RTKs (3). In human cancer tissues, c-Cbl is frequently tyrosine-phosphorylated in a tumor-specific manner (5). Phosphorylation of Tyr731 of c-Cbl provides a docking site for downstream signaling components such as p85 and Fyn (6).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验CD49a/CD49b/CD49c/CD49d/CD49e/CD49f分子
CD49a/CD49b/CD49c/CD49d/CD49e/CD49f 分子 CD49a 常用单克隆抗体或代号： SR84,IB3.1;(VLAa 1) 主要表达细胞： Ta,Ba,M [AS] 分子质量(kDa)和结构： gp210,与CD29组成VLA- 1 功 能： 粘附CA和LM CD49b 常用单克隆抗体或代号： Gi94;(VLA- a 2,ECMR- Ⅱ,Pt- GPIa) 主要表达细胞： Leu,Pt,Fb,En [AS] 分子
Although the rabbit is used extensively in developmental toxicity testing, relatively little is known about the fundamental developmental biology of this species let alone mechanisms underlying developmental toxicity. This paucity
Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
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