Deltex-2 Antibody

Deltex-2 Antibody

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  • 询价
  • Cell Signaling Technology已认证
  • USA
  • 2025年10月18日
  • W, IP
  • Rabbit
  • M,H,R
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    • 详细信息
    • 技术资料
    • 抗体英文名

      Deltex-2 Antibody

    • 抗原

      synthetic peptide corresponding to residues surrounding Ala607 of human Deltex-2

    • 应用范围

      W, IP

    • 宿主

      Rabbit

    • 适应物种

      M,H,R

    • 库存

      大量

    • 级别

      详见MSDS文件

    • 供应商

      CST

    • 保质期

      详见说明书

    • 是否单克隆

      2

    • 保存条件

      -20°c

    • 规格

      100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting  IP=Immunoprecipitation
    Reactivity Key:  H=Human  M=Mouse  R=Rat
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Source
    W IP M (H) (R) Transfected Only 70 Rabbit
    Protocols
    Specificity / Sensitivity

    Deltex-2 Antibody detects transfected levels of total Deltex-2 protein.

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala607 of human Deltex-2. Antibodies are purified by protein A and peptide affinity chromatography.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts from COS cells, untransfected or transfected with mouse Deltex-2, using Deltex-2 Antibody.

    Background

    Deltex (DTX) encodes a putative E3 ubiquitin ligase first identified from Drosophila and shown to modulate Notch signaling (1). Several mammalian Deltex homologs have been isolated (2,3), all containing a pair of WWE repeats, a proline-rich region, and a Ring-finger domain (4,5). Deltex binds to the ankyrin-repeat domain of Notch and is capable of regulating Notch signaling positively or negatively in different systems (4,6). In addition, Deltex can also form homo-multimers (4). While Deltex has been implicated in Notch signaling regulation of lymphocyte development, this signal modifier may also have a transcriptional function independent of Notch (3, 6-8).

    1. Xu, T. and Artavanis-Tsakonas, S. (1990) Genetics 126, 665-77.
    2. Kishi, N. et al. (2001) Int J Dev Neurosci 19, 21-35.
    3. Lehar, S.M. and Bevan, M.J. (2006) Mol Cell Biol 26, 7358-71.
    4. Matsuno, K. et al. (1995) Development 121, 2633-44.
    5. Zweifel, M.E. et al. (2005) Structure 13, 1599-611.
    6. Izon, D.J. et al. (2002) Immunity 16, 231-43.
    7. Yun, T.J. and Bevan, M.J. (2003) J Immunol 170, 5834-41.
    8. Yamamoto, N. et al. (2001) J Biol Chem 276, 45031-40.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    For Research Use Only. Not For Use In Diagnostic Procedures.

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