Eg5 Antibody

Eg5 Antibody

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  • 询价
  • Cell Signaling Technology已认证
  • USA
  • 2025年10月07日
  • W, IP
  • Rabbit
  • H
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    • 详细信息
    • 技术资料
    • 抗体英文名

      Eg5 Antibody

    • 抗原

      synthetic peptide corresponding to residues near the carboxy terminus of human Eg5 protein

    • 应用范围

      W, IP

    • 宿主

      Rabbit

    • 级别

      详见MSDS文件

    • 供应商

      CST

    • 适应物种

      H

    • 库存

      大量

    • 保质期

      详见说明书

    • 是否单克隆

      2

    • 保存条件

      -20°c

    • 规格

      100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting  IP=Immunoprecipitation
    Reactivity Key:  H=Human
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Source
    W IP H Endogenous 120 Rabbit
    Protocols
    Specificity / Sensitivity

    Eg5 Antibody recognizes endogenous levels of total Eg5 protein.

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Eg5 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts from various cell lines using Eg5 Antibody.

    Background

    Eg5 (also called kinesin-like protein 11 or Kif11) belongs to the kinesin-like family of motor proteins important in chromosome positioning, centrosome separation, and mitotic spindle formation. Phosphorylation of Eg5 by mitotic kinases regulates its activity by modulating its association with microtubules (1,2). Because anti-mitotic chemotherapeutic drugs, such as taxanes, target microtubules and have pleiotropic and sometimes toxic effects, drugs that target microtubule-associated proteins such as Eg5 are currently in development (3-5).

    1. Blangy, A. et al. (1995) Cell 83, 1159-69.
    2. Rapley, J. et al. (2008) J Cell Sci 121, 3912-21.
    3. Sarli, V. and Giannis, A. (2006) ChemMedChem 1, 293-8.
    4. Cox, C.D. et al. (2008) J Med Chem 51, 4239-52.
    5. Nakai, R. et al. (2009) Cancer Res 69, 3901-9.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    For Research Use Only. Not For Use In Diagnostic Procedures.

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