- 询价
- Cell Signaling Technology
- 3814
- USA
- 2025年10月04日
- W
- Rabbit
- H,M,R,Mk
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- 详细信息
- 技术资料
- 抗体英文名：
Bak Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding Gly82 of human Bak
- 应用范围：
W
- 宿主：
Rabbit
- 供应商：
CST
- 适应物种：
H,M,R,Mk
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 库存：
大量
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R Mk | Endogenous | 25 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Bak Antibody detects endogenous levels of Bak protein. No cross reactivity was detected with other Bcl-2 family members. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly82 of human Bak. Antibodies were purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from OVCAR8, HT29 and Jurkat cells using Bak Antibody. |
| Background | Bak is a proapoptotic member of the Bcl-2 family (1). This protein is located on the outer membrane of mitochondria and is an essential component for transduction of apoptotic signals through the mitochondrial pathway (2,3). Upon apoptotic stimulation, an upstream stimulator like truncated BID (tBID) induces conformational changes in Bak to form oligomer channels in the mitochondrial membrane for cytochrome c release. The release of cytochrome c to the cytosol activates the caspase-9 pathway and eventually leads to cell death (4,5). |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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