相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Amino acids 76 – 170 of human PUMA-alpha.
- 亚型:
mouse IgG1
- 形态:
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.02% sodium azide. Antibody was purified by Protein-A affinity chromatography.
- 保存条件:
Store at 4°C.
- 克隆性:
单克隆
- 标记物:
见下方详细说明
- 适应物种:
H, R
- 保质期:
1-2年
- 抗原来源:
Amino acids 76 – 170 of human PUMA-alpha.
- 目录编号:
253256
- 级别:
超纯
- 库存:
大量
- 供应商:
Abbiotec
- 宿主:
Mouse
- 应用范围:
E, WB
- 浓度:
见详细说明信息
- 靶点:
PUMA (10C5G1)
- 抗体英文名:
PUMA (10C5G1) Antibody
- 抗体名:
PUMA (10C5G1) Antibody
- 规格:
0.1 mg
PUMA (10C5G1) Antibody产品详细介绍:
| 产品名称: | PUMA (10C5G1) Antibody |
| 说明书: | 【点击查看详细说明及参考图片】 |
| 货号: | 253256 |
| 规格: | 0.1 mg |
| 产品描述: | Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. |
| 克隆类型: | Mouse Monoclonal Antibody |
| 亚型: | mouse IgG1 |
| 免疫原: | Amino acids 76 – 170 of human PUMA-alpha. |
| 适用物种: | H, R |
| 应用范围: | E, WB |
| 应用说明: | E: 1:500-1:1,000; WB: 1:100-1:500 |
| 别名: | PUMA; p53 upregulated modulator of apoptosis; bbc3; Bcl-2 binding component 3 |
| 形态: | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.02% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存条件: | Store at 4°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献: |
ABBIOTEC产品提供质量保证,提供完善的售后和技术支持,ABBIOTEC产品正品包装:
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验体免疫系统对抗病毒,防止病毒引发疾病。 在这篇文章中,研究人员提出了一种流感血凝素特异性单克隆抗体:Y8-10C2(Y8)的细胞内对抗病毒的新机制,这种抗体只有在酸性环境下才具有对抗病毒的活性,研究人员发现了这一抗体作用活性需要利用新生儿Fc受体FcRn,通过FcRn的协同作用,Y8就能进入被感染的细胞内,关闭病毒的复制。 进一步的研究发现缺失FcRn的小鼠,即使存在病毒特异性IgG,也不能有效的击退流感病毒感染,但是正常的小鼠可以。但是如果是在细胞内对抗病毒感染,那么就不要FcRn这种免疫
secondary antibody review -- data from 99 publications
cytometry used as a control to detect cell responses targeted antigen 7 Alexa Fluor 488 7 Cy3 8 goat IgG Alexa Fluor 488 1:2000 detect antibody binding in human embryonic kidney 293T cells Invitrogen 9 donkey
作用。 (三)BH3-Only亚族 这一亚族成员仅含有一个BH同源结构域,即BH3结构域,包括Bid、Bad和Bim等。BH3-only蛋白本身在无Bax或Bak的情况下不能引起细胞凋亡,因此可能通过为Bax/Bak传递凋亡信号而发挥作用。细胞中的BH3-only蛋白的活动空间是被严格限制的,如Bim和Bmf通过动力蛋白轻链(dyneinlightchain,DLC)分别固定在微管和肌动蛋白骨架上。基因敲除实验显示,BH3-only蛋白在不同组织器官中发挥作用,如Bid调节Fas抗体引起的肝细胞
技术资料暂无技术资料 索取技术资料










